Citalopramum
From Wikipedia, the free encyclopedia
From Wikipedia, the free encyclopedia
Citalopramum est substantia psychoanaleptica, antidepressiva et inhibitor reabsorptionis serotonini selectivi[1]. Quae ad conturbationem obsessionem-compulsionem et phobias curandas adhibetur.
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Cave: notitiae huius paginae nec praescriptiones nec consilia medica sunt. |
| Citalopramum |
|---|
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| Natura pharmacologia |
| Tempus semivitae biologicum: 35 h |
| Res legis |
  praescriptionem oportet |
Structura chemica (RS)-1-(3-Dimethylaminopropyl)-1-(4-fluorphenyl)-3H-2-benzofuran-5-carbonitrilum et massa molaris 324.39 g/mol est. Codex ATC est N06AB04.
Citalopramum imprimis inhibitor reabsorptionis serotonini affinitate sui notate cum transportatore serotonini (SERT) est, Ki = 1.6 (Sertralinum: 2.0) habens.
Praeterea Citalopramum histamini- et serotonini- et adrenergica et acetylcholini muscarinicareceptoria obsidet.
| Receptorium | Affinitas ligandi, Ki (nM)[2] |
|---|---|
| transportator serotonini (SERT) | 1.6 — 5.4[1] |
| transportator noradrenalini (NET) | 6190 |
| serotonini 5-HT2C | 617 |
| adrenergicorum α1 | 1211 |
| muscarinicum acetylcholini M1 | 1430 |
| histamini H1 | 283 |
Tempus semivitae biologicum longus (circa 36 horae) est.[3] Citalopramum cytochromatis CYP2D6 inhibitor est. Excretio est per urinas.
Exempli (!) sunt:
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