Dopamina[1][2] est compositum organicum et neurotransmissor in cerebro, quo munera systematum et remunerationis et extrapyramidalis (motuum) habet.
Cognitores | |
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ChemSpider | 661 |
PubChem | 681 |
DrugBank | DB00988 |
Natura chemica | |
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Formula summarum | C 8H 11NO 2 |
Massa molaris | 153.181 g/mol |
In nonnullis cerebri structuris dopamina abunde invenitur, ut in substantia nigra. Inopia dopaminae morbo Parkinson signum morbi proprium attribuebatur.
Receptoria neurotransmissoris quae ad dopaminam spectant, dopaminergica nominantur.
Nomen IUPAC est 4-(2-amino-aethyl)-benzino-1,2-diolum. Simul est catecholaminum, quare dopaminae greges et catecholi et aminae insunt.
- Catecholum
- Phenyl-aethyl-aminum
Dopamina per enzymum dopamini beta-hydroxylasis in neurotransmissorem noradrenalinam transvertitur.
In organismo, dopamina est et hormon et neurotransmissor.[3] Synthesis imprimis ex aminoacido phenylalaninae fit, quod per aminoacida ipsa tyrosinae et laevodopa (L-DOPA, 3,4-dihydroxyphenylalanina) in dopaminam convertitur. Degradatio dopaminae per enzyma MAO-B et COMT fit.
Dopamina neurotransmissor
In systematis nervosi centralis dopamina est neurotransmissor, quae receptoria dopaminergica, ut D2 obsidet. Liberatur dopamina de neuronibus substantiae nigrae et areae tegmentalis ventralis.
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