DNA repair-deficiency disorder

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がんではDNA修復遺伝子の発現の欠乏が非常に高頻度でみられる。生殖細胞系列におけるDNA修復遺伝子の変異による欠陥はがんのリスクを高めることが知られており（遺伝性腫瘍症候群、en:DNA repair-deficiency disorder