7-デヒドロコレステロールレダクターゼ(7-dehydrocholesterol reductase、DHCR7)は、ヒトのDHCR7遺伝子にコードされているタンパク質である[1][2][3]。
このタンパク質はNADPHを用いて7-デヒドロコレステロール(7-DHC)からコレステロールを合成する酵素である。
DHCR7遺伝子には7-デヒドロコレステロール(EC 1.3.1.21)がコードされており、これは哺乳動物におけるステロール生合成の最後から2番目の酵素である。この酵素はステロールΔ8-Δ7イソメラーゼによって導入されたC(7-8)二重結合を除去する。
欠損症はスミス-レムリ-オピッツ症候群(コレステロール代謝異常による先天性奇形疾患)に関連する。
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