5-(カルボキシアミノ)イミダゾールリボヌクレオチドムターゼ(5-(carboxyamino)imidazole ribonucleotide mutase)はプリン塩基のde novo合成に関わる酵素であり、以下の化学反応を触媒する異性化酵素である。
- 5-カルボキシアミノ-1-(5-ホスホ-D-リボシル)イミダゾール 5-アミノ-1-(5-ホスホ-D-リボシル)イミダゾール-4-カルボン酸
| 5-(カルボキシアミノ)イミダゾールリボヌクレオチドムターゼ | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 識別子 | |||||||||
| EC番号 | 5.4.99.18 | ||||||||
| CAS登録番号 | 255379-40-9 | ||||||||
| データベース | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB構造 | RCSB PDB PDBj PDBe PDBsum | ||||||||
| |||||||||
系統名は、5-カルボキシアミノ-1-(5-ホスホ-D-リボシル)イミダゾール カルボキシムターゼ(5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase)である。
出典
- Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM (1992). “Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway”. Biochemistry. 31 (21): 5022–32. doi:10.1021/bi00136a016. PMID 1534690.
- Mueller EJ, Meyer E, Rudolph J, Davisson VJ, Stubbe J (1994). “N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli”. Biochemistry. 33 (8): 2269–78. doi:10.1021/bi00174a038. PMID 8117684.
- Meyer E, Kappock TJ, Osuji C, Stubbe J (1999). “Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase”. Biochemistry. 38 (10): 3012–8. doi:10.1021/bi9827159. PMID 10074353.
- Mathews II, Kappock TJ, Stubbe J, Ealick SE (1999). “Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway”. Structure. 7 (11): 1395–406. doi:10.1016/S0969-2126(00)80029-5. PMID 10574791.
- Firestine SM, Poon SW, Mueller EJ, Stubbe J, Davisson VJ (1994). “Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms”. Biochemistry. 33 (39): 11927–34. doi:10.1021/bi00205a031. PMID 7918411.
- Davisson VJ; Misialek, S; Toffaletti, DL; Klem, TJ; Perfect, JR; Davisson, VJ (1998). “Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis”. Arch. Biochem. Biophys. 351 (1): 123–34. doi:10.1006/abbi.1997.0512. PMID 9500840.
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