2,4-ジエノイルCoAレダクターゼ (NADPH)（2,4-dienoyl-CoA reductase (NADPH)）は、次の化学反応を触媒する酸化還元酵素である。
- trans-2,3-ジデヒドロアシルCoA + NADP+ trans,trans-2,3,4,5-テトラデヒドロアシルCoA + NADPH + H+
| 2,4-ジエノイルCoAレダクターゼ (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 識別子 | |||||||||
| EC番号 | 1.3.1.34 | ||||||||
| CAS登録番号 | 82869-38-3 | ||||||||
| データベース | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB構造 | RCSB PDB PDBj PDBe PDBsum | ||||||||
| 遺伝子オントロジー | AmiGO / QuickGO | ||||||||
| |||||||||
反応式の通り、この酵素の基質はtrans-2,3-ジデヒドロアシルCoAとNADP+、生成物はtrans,trans-2,3,4,5-テトラデヒドロアシルCoAとNADPHとH+である。
組織名はtrans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductaseで、別名に4-enoyl-CoA reductase (NADPH), 4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase, 4-enoyl-CoA reductase, 2,4-dienoyl-CoA reductase (NADPH)がある。
参考文献
- Dommes, V., Luster, W., Cvetanovic, M. and Kunau, W.-H. (1982). “Purification by affinity chromatography of 2,4-dienoyl-CoA reductases from bovine liver and Escherichia coli.”. J. Biochem. 125: 335-341. PMID 6749495.
- Kunau, W.-H. and Dommes, P. (1978). “Degradation of unsaturated fatty acids. Identification of intermediates in the degradation of cis-4-decenoly-CoA by extracts of beef-liver mitochondria.”. J. Biochem. 91: 533-544. PMID 729581.
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