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ニコチンデヒドロゲナーゼ(nicotine dehydrogenase)は、ニコチン酸、ニコチンアミド代謝酵素の一つで、次の化学反応を触媒する酸化還元酵素である。
- (R,S)-ニコチン + 受容体 + H2O (R,S)-6-ヒドロキシニコチン + 還元型受容体
反応式の通り、この酵素の基質は(R,S)-ニコチンと受容体とH2O、生成物は(R,S)-ヒドロキシニコチンと還元型受容体である。
組織名はnicotine:acceptor 6-oxidoreductase (hydroxylating)で、別名にnicotine oxidase、D-nicotine oxidase、nicotine:(acceptor) 6-oxidoreductase (hydroxylating)、L-nicotine oxidaseがある。
- BEHRMAN EJ, STANIER RY (1957). “The bacterial oxidation of nicotinic acid”. J. Biol. Chem. 228: 923–45. PMID 13475371.
- Decker K, Bleeg H (1965). “Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans”. Biochim. Biophys. Acta. 105: 313–24. PMID 5849820.
- Hochstein LI, Dalton BP (1967). “The purification and properties of nicotine oxidase”. Biochim. Biophys. Acta. 139: 56–68. PMID 4962139.
- HOCHSTEIN LI, RITTENBERG SC (1959). “The bacterial oxidation of nicotine. II. The isolation of the first oxidative product and its identification as (1)-6-hydroxynicotine”. J. Biol. Chem. 234: 156–60. PMID 13610912.
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