グルコセレブロシダーゼ

GBA
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1OGS, 1Y7V, 2F61, 2J25, 2NSX, 2NT0, 2NT1, 2V3D, 2V3E, 2V3F, 2VT0, 2WCG, 2WKL, 2XWD, 2XWE, 3GXD, 3GXF, 3GXI, 3GXM, 3KE0, 3KEH, 3RIK, 3RIL
識別子
記号	GBA, GBA1, GCB, GLUC, glucosylceramidase beta, Glucocerebrosidase
外部ID	OMIM: 606463 MGI: 95665 HomoloGene: 68040 GeneCards: GBA
遺伝子の位置 (ヒト)
染色体	1番染色体 (ヒト)
終点	155,244,699 bp
遺伝子の位置 (マウス)
染色体	3番染色体 (マウス)
終点	89,116,273 bp
RNA発現パターン
	; ;
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• hydrolase activity, acting on glycosyl bonds; • 血漿タンパク結合; • 加水分解酵素活性; • 受容体結合; • glucosylceramidase activity;
細胞の構成要素	• 膜; • リソソーム; • エキソソーム; • lysosomal lumen; • lysosomal membrane; • 細胞外空間;
生物学的プロセス	• termination of signal transduction; • skin morphogenesis; • glycosphingolipid metabolic process; • positive regulation of protein dephosphorylation; • 脂質代謝; • response to testosterone; • cellular response to starvation; • negative regulation of interleukin-6 production; • response to thyroid hormone; • ceramide biosynthetic process; • cellular response to tumor necrosis factor; • sphingosine biosynthetic process; • positive regulation of proteolysis involved in cellular protein catabolic process; • regulation of water loss via skin; • response to estrogen; • glucosylceramide catabolic process; • negative regulation of MAP kinase activity; • response to pH; • 代謝; • negative regulation of inflammatory response; • regulation of macroautophagy; • sphingolipid metabolic process; • mitochondrion organization; • neuron projection development; • regulation of cellular protein metabolic process; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • negative regulation of protein homooligomerization; • cell death in response to oxidative stress; • positive regulation of protein-containing complex disassembly; • regulation of protein metabolic process; • negative regulation of neuron death; • positive regulation of protein lipidation; • positive regulation of neuronal action potential; • positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization; • autophagosome organization; • regulation of lysosomal protein catabolic process; • beta-glucoside catabolic process; • デキサメタゾンへの反応;
	出典:Amigo / QuickGO
オルソログ
	2629
	14466
	ENSG00000262446; ENSG00000177628
	ENSMUSG00000028048
	P04062
	P17439
NM_000157; NM_001005741; NM_001005742; NM_001005749; NM_001005750;
	NM_001171811; NM_001171812
	NM_001077411; NM_008094
	NP_000148; NP_001005741; NP_001005742; NP_001165282; NP_001165283
	NP_001070879; NP_032120
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス