アロゲン酸デヒドロゲナーゼ (NADP+)（arogenate dehydrogenase (NADP+)）は、次の化学反応を触媒する酸化還元酵素である。
- L-アロゲン酸 + NADP+ L-チロシン + NADPH + CO2
| アロゲン酸デヒドロゲナーゼ (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 識別子 | |||||||||
| EC番号 | 1.3.1.78 | ||||||||
| CAS登録番号 | 64295-75-6 | ||||||||
| データベース | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB構造 | RCSB PDB PDBj PDBe PDBsum | ||||||||
| 遺伝子オントロジー | AmiGO / QuickGO | ||||||||
| |||||||||
反応式の通り、この酵素の基質はL-アロゲン酸とNADP+、生成物はL-チロシンとNADPHと二酸化炭素である。
組織名はL-arogenate:NADP+ oxidoreductase (decarboxylating)で、別名にarogenic dehydrogenase (ambiguous), pretyrosine dehydrogenase (ambiguous), TyrAAT1, TyrAAT2, TyrAaがある。
- Byng G, Whitaker R, Flick C and Jensen RA (1981). “Enzymology of L-tyrosine biosynthesis in corn (Zea mays)”. Phytochemistry 20: 1289–1292. doi:10.1016/0031-9422(81)80023-4.
- Gaines CG, Byng GS, Whitaker RJ and Jensen RA (1982). “L-Tyrosine regulation and biosynthesis via arogenate dehydrogenase in suspension-cultured cells of Nicotiana silvestris Speg. et Comes”. Planta 156: 233–240. doi:10.1007/BF00393730.
- Ishikawa T, Hirayama J, Kobayashi Y, Todo T (2002). “Zebrafish CRY represses transcription mediated by CLOCK-BMAL heterodimer without inhibiting its binding to DNA”. Genes. Cells. 7: 1073–86. doi:10.1046/j.1365-2443.2002.00579.x. PMID 12354100.
- Bonner CA, Jensen RA, Gander JE, Keyhani NO (2004). “A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis”. Biochem. J. 382: 279–91. doi:10.1042/BJ20031809. PMID 15171683.
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