NAD(P)Hオキシダーゼ

NAD(P)Hオキシダーゼ（NAD(P)H oxidase）は、次の化学反応を触媒する酸化還元酵素である。

NAD(P)H + H⁺ + O₂ ${\displaystyle \rightleftharpoons }$ NAD(P)⁺ + H₂O₂

NAD(P)Hオキシダーゼ
識別子
EC番号	1.6.3.1
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBj PDBe PDBsum
遺伝子オントロジー	AmiGO / QuickGO
検索 PMC articles PubMed articles NCBI proteins

反応式の通り、この酵素の基質はNADH（NADPH）とH⁺とO₂、生成物はNAD⁺（NADP⁺）とH₂O₂である。

組織名はNAD(P)H:oxygen oxidoreductaseで、別名にTHOX2; ThOX; dual oxidase; p138tox; thyroid NADPH oxidase; thyroid oxidase; thyroid oxidase 2; NADPH oxidaseがある。

参考文献

• Vijlder JJ, Vulsma T, Ris-Stalpers C (2002). “Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism”. N. Engl. J. Med. 347: 95–102. doi:10.1056/NEJMoa012752. PMID 12110737.
• De Deken X, Wang D, Dumont JE, Miot F (2002). “Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system”. Exp. Cell. Res. 273: 187–96. doi:10.1006/excr.2001.5444. PMID 11822874.
• Dumont JE, Miot F (2000). “Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family”. J. Biol. Chem. 275: 23227–33. doi:10.1074/jbc.M000916200. PMID 10806195.
• Dupuy C, Ohayon R, Valent A, Noel-Hudson MS, Deme D, Virion A (1999). “Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas”. J. Biol. Chem. 274: 37265–9. doi:10.1074/jbc.274.52.37265. PMID 10601291.
• Carvalho D, Dupuy C, Virion A (1999). “Biochemical characterization of a Ca2+/NAD(P)H-dependent H2O2 generator in human thyroid tissue”. Biochimie. 81: 373–80. doi:10.1016/S0300-9084(99)80084-4. PMID 10401672.
• Dupuy C, Virion A, Ohayon R, Kaniewski J, Deme D, Pommier J (1991). “Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane”. J. Biol. Chem. 266: 3739–43. PMID 1995628.