ペリオスチン (periostin) は、ヒトのPOSTN遺伝子にコードされたタンパク質である[5][6]。ペリオスチンはαVβ3(英語版)およびαVβ5(英語版)インテグリンのリガンドとして機能し、上皮細胞の接着および遊走を支える[7]。
喘息
ペリオスチンは喘息と関連している。これは、喘息の試験薬であるレブリキズマブ (lebrikizumab) に利用されている[8]。
癌
ペリオスチンの過剰発現は様々な種類の癌で報告されており、腫瘍細胞の環境で最も頻繁に見られる[7][9]。最近研究では、ペリオスチンは正常組織や原発腫瘍間質中の線維芽細胞によって発現される細胞外マトリックスの構成要素であることが明らかにされている。転移性コロニー形成は 浸潤性がん細胞によるストロマ中のペリオスチンの誘導が必要である。ペリオスチンの産生はTGF-β2あるいはTGF-β3によって肺線維芽細胞において上方制御される。TGF-β3は浸潤性がん幹細胞によって分泌される(MMTV-PyMTマウス乳癌モデル)[10]。
さらに見る 細胞株, 起源 ...
様々ながん細胞株におけるペリオスチンの発現[11]
細胞株 | 起源 | POSTN/ACTB1 |
U2OS | 骨肉腫 | 3.5±1.7 |
LB96 | ユーイング肉腫 | 0 |
LB23-1 | 横紋筋肉腫 | 0.1±0.1 |
HeLa | 子宮頸癌 | 3.0±0.4 |
PA-1 | 卵巣奇形腫 | 1.4±0.1 |
LB37-1 | NSCLC | 2.8±0.6 |
LB85 | SCLC | 3.4±0.2 |
LB92 | SCLC | 0.6±0.2 |
LB1047 | 腎細胞癌 | 0.8±0.2 |
BB64 | 腎細胞癌 | 0.08±0.01 |
LB108 | 結腸直腸癌 | 0 |
MCF7 | 乳癌 | 0 |
Hs578T | 乳癌 | 3693±86 |
Panc-1 | 膵癌 | 0 |
Capan-1 | 膵癌 | 0 |
Huh-7 | 肝細胞癌 | 0.3±0.07 |
LB831 | 膀胱癌 | 1748±74 |
MZGC3 | 胃癌 | 0 |
A172 | 膠芽腫 | 45±4 |
MZ2 | メラノーマ | 2.3±0.7 |
LB39 | メラノーマ | 0.5±0.03 |
LB2586-7 | メラノーマ | 3.4±0.3 |
LB2201-3 | メラノーマ | 4.2±0.4 |
A375 | メラノーマ | 4.7±1.2 |
閉じる
1 (cDNA POSTN/cDNA ACTB) × 104
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