| Attore | Personaggio | Durata |
| Macdonald Carey | Tom Horton | 1965-1994 |
| Frances Reid | Alice Horton | 1965-2007 |
| John Clarke | Mickey Horton | 1965-2004 |
| Richard Voigts | Mickey Horton | 2004 |
| John Ingle | Mickey Horton | 2004-2006 |
| Kevin Dobson | Mickey Horton | 2008 |
| Maree Cheatham | Marie Horton | 1965-1968, 1970–1971, 1973, 1994, 1996, 2010, 2024 |
| Katherine Woodville | Marie Horton | 1977 |
| Charla Doherty | Julie Olson | 1965–1966 |
| Catherine Dunn | Julie Olson | 1967 |
| Catherine Ferrar | Julie Olson | 1967–1968 |
| Richard Colla | Tony Merritt | 1965-1966 |
| Don Briscoe | Tony Merritt | 1966 |
| Ron Husmann | Tony Merritt | 1966-1967 |
| David McLean | Craig Merritt | 1965-1967 |
| Harry Lauter | Craig Merritt | 1966 |
| John Lupton | Tommy Horton | 1967–1973, 1975–1980 |
| Patricia Huston | Addie Horton | 1965–1966 |
| Patricia Barry | Addie Horton | 1971–1974 |
| Paul Carr | Bill Horton | 1965–1966 |
| Edward Mallory | Bill Horton | 1966-1980, 1991, 1992 |
| Christopher Stone | Bill Horton | 1987-1988, 1994 |
| John H. Martin | Bill Horton | 2010 |
| Floy Dean | Laura Horton | 1966 |
| Susan Flannery | Laura Horton | 1966–1975 |
| Susan Oliver | Laura Horton | 1975–1976 |
| Rosemary Forsyth | Laura Horton | 1976–1980 |
| Jaime Lyn Bauer | Laura Horton | 1993–1999, 2003, 2010, 2013, 2016, 2018, 2021 |
| Robert Knapp | Ben Olson | 1965 |
| Flip Mark | Steve Olson | 1965-1966 |
| James Carroll Jordan | Steve Olson | 1972 |
| Stephen Schnetzer | Steve Olson | 1978–1980, 2024 |
| Regina Gleason | Kitty Horton | 1967-1969 |
| Astrid Warner | Sandy Horton | 1967 |
| Heather North | Sandy Horton | 1967–1972 |
| Martha Smith | Sandy Horton | 1982 |
| Pamela Roylance | Sandy Horton | 1983–1984 |
| Jean Bruce Scott | Jessica Blake | 1980–1982, 2012 |
| Kyle Puerner | Mike Horton | 1968–1969 |
| Wade Holdsworth | Mike Horton | 1969 |
| Brian Andrews | Mike Horton | 1970 |
| Bobby Eilbacher | Mike Horton | 1970 |
| Eddie Rayden | Mike Horton | 1970 |
| Alan Decker | Mike Horton | 1970–1971 |
| John Amour | Mike Horton | 1971–1973 |
| Dick DeCoit | Mike Horton | 1973 |
| Stuart Lee | Mike Horton | 1973 |
| Wesley Eure | Mike Horton | 1974–1981 |
| Paul Coufus | Mike Horton | 1981–1982 |
| Michael T. Weiss | Mike Horton | 1985–1990 |
| Roark Critchlow | Mike Horton | 1994–1999, 2010, 2022 |
| Maren Stephenson | Jennifer Horton | 1976–1977 |
| Jennifer Peterson | Jennifer Horton | 1977–1979 |
| Stephanie Cameron | Jennifer Horton | 1995–1998 |
| Cady McClain | Jennifer Horton | 2020–2024 |
| Bryan Dattilo | Lucas Horton | 1993-2010, 2012-2024 |
| Joseph Trent Everett | Melissa Horton | 1971 |
| Matthew Bowman | Melissa Horton | 1971 |
| Kim Durso | Melissa Horton | 1975–1976 |
| Debbie Lytton | Melissa Horton | 1977–1980, 1982–1983 |
| Lisa Trusel | Melissa Horton | 1983–1988, 1994, 1996, 2002, 2010 |
| Camilla Scott | Melissa Horton | 1990–1991 |
| Colin Lewis | Sarah Horton | 1981 |
| Anthony Seaward | Sarah Horton | 1981–1982 |
| Katie Krell | Sarah Horton | 1982–1985 |
| Lisa Brinegar | Sarah Horton | 1985–1989 |
| Shauna Lane-Block | Sarah Horton | 1989–1990 |
| Aimee Brooks | Sarah Horton | 1990 |
| Alli Brown | Sarah Horton | 1991 |
| Bill Hayes | Doug Williams | 1970-1984, 1986-1987, 1993-1996, 1999-2024 |
| Kristina Osterhaut | Hope Williams | 1974 |
| Kimberley Webber | Hope Williams | 1974-1975 |
| Natasha Ryan | Hope Williams | 1975-1980 |
| Tammy Taylor | Hope Williams | 1980-1981 |
| Mila Kunis | Hope Williams | 1994 |
| Chad Eric Barstad | David Banning | 1967–1970 |
| Jeffrey William | David Banning | 1970–1973 |
| Steve Doubet | David Banning | 1975 |
| Richard Guthrie | David Banning | 1975–1981 |
| Gregg Marx | David Banning | 1981–1983 |
| Tina Andrews | Valerie Grant | 1975–1977 |
| Rose Fonseca | Valerie Grant | 1977–1978 |
| Diane Sommerfield | Valerie Grant | 1981–1982 |
| Vanessa A. Williams | Valerie Grant | 2016–2022 |
| Michael Dwight Smith | Danny Grant | 1978 |
| Roger Aaron Brown | Danny Grant | 1981-1985 |
| Scott Shilstone | Zack Brady | 2016 |
| Jeremy Allen | Jeremy Horton | 1989 |
| Jeffrey Clark | Jeremy Horton | 1989 |
| Trevor Donovan | Jeremy Horton | 2007 |
| Joseph Campanella | Harper Deveraux | 1986–1988, 1990–1992 |
| Joseph Adams | Jack Deveraux | 1987 |
| James Acheson | Jack Deveraux | 1987 |
| Steve Witmer | Jack Deveraux | 1994 |
| Mark Valley | Jack Deveraux | 1994–1997 |
| Steve Wilder | Jack Deveraux | 1997–1998 |
| Jane Elliot | Anjelica Deveraux | 1987-1989 |
| Shelley Taylor Morgan | Anjelica Deveraux | 1989 |
| Judith Chapman | Anjelica Deveraux | 1989-1991, 2018 |
| Morgan Fairchild | Anjelica Deveraux | 2017 |
| Megan Corletto | Abigail Deveraux | 2001–2003 |
| Jillian Clare | Abigail Deveraux | 2003–2004 |
| Ashley Benson | Abigail Deveraux | 2004–2007 |
| Emily Montague | Abigail Deveraux | 2007 |
| Kate Mansi | Abigail Deveraux | 2011–2016, 2018–2020 |
| Marci Miller | Abigail Deveraux | 2016–2018, 2020–2022 |
| Tyler Lake | JJ Deveraux | 2004–2005 |
| Darian Weiss | Will Horton | 2002–2003 |
| Christopher Gerse | Will Horton | 2003–2008 |
| Dylan Patton | Will Horton | 2009–2010 |
| Guy Wilson | Will Horton | 2014–2015 |
| Lindsay Arnold | Allie Horton | 2020–2023 |
| Blake Berris | Nick Fallon | 2006-2009, 2012-2014, 2021, 2023 |
| Mark Hapka | Nathan Horton | 2009-2011 |
| Frank Parker | Shawn Brady | 1983–2008 |
| Lew Brown | Shawn Brady | 1984–1985 |
| Peter MacLean | Shawn Brady | 1989–1990 |
| Drew Snyder | Shawn Brady | 2019 |
| Peggy McCay | Caroline Brady | 1983, 1985–2016 |
| Jody Carter | Caroline Brady | 1983–1984 |
| Barbara Beckley | Caroline Brady | 1984–1985 |
| Holgie Forrester | Caroline Brady | 2019 |
| Shirley Jones | Colleen Brady | 2007–2008 |
| Robert Hanley | Eric Brady I | 1982 |
| Scott Marlowe | Eric Brady I | 1984 |
| Wayne Northrop | Roman Brady | 1981–1984, 1991–1994 |
| Catherine Mary Stewart | Kayla Brady | 1982–1983 |
| Rhonda Aldrich | Kayla Brady | 1989 |
| Robert Kelker-Kelly | Bo Brady | 1992–1995 |
| Patsy Pease | Kimberly Brady | 1984–1992, 1994–2016 |
| Anne Howard | Kimberly Brady | 1990–1991 |
| Ariana Chase | Kimberly Brady | 1992–1993 |
| Casey Wallace | Kimberly Brady | 1992 |
| Billy Warlock | Frankie Brady | 1986–1988, 1990–1991, 2005–2006 |
| Michael Rhoton | Max Brady | 1986–1987 |
| Adrian Arnold | Max Brady | 1987 |
| Ryan Brennan | Max Brady | 1987–1988, 1990–1992 |
| Darin Brooks | Max Brady | 2005–2010 |
| Andrea Barber | Carrie Brady | 1982–1986 |
| Tracy Middendorf | Carrie Brady | 1992 |
| Dan Wells | Sami Brady | 2005 |
| Edward Palma | Eric Brady | 1986 |
| Bradley Hallock | Eric Brady | 1986-1992 |
| Jensen Ackles | Eric Brady | 1997–2000 |
| Jason Gerhardt | Eric Brady | 2023 |
| Eric Winter | Rex Brady | 2002–2005 |
| Alexis Thorpe | Cassie Brady | 2002–2005 |
| Noel Bennett Castle | Shawn Douglas Brady | 1987 |
| Paul Zachary | Shawn Douglas Brady | 1990 |
| Scott Groff | Shawn Douglas Brady | 1990–1995 |
| Collin O'Donnell | Shawn Douglas Brady | 1995–1999 |
| Jason Cook | Shawn Douglas Brady | 1999–2006, 2015 |
| Mandy Musgrave | Chelsea Brady | 2004–2005 |
| Rachel Melvin | Chelsea Brady | 2005–2009, 2023 |
| Lauren Boles | Ciara Brady | 2008–2015 |
| Vivian Jovanni | Ciara Brady | 2015–2017 |
| Victoria Konefal | Ciara Brady | 2017–2024 |
| Alina Foley | Claire Brady | 2008 |
| Olivia Rose Keegan | Claire Brady | 2015–2020 |
| Isabel Durant | Claire Brady | 2020–2021 |
| Robert Poynton | John Black | 1985–1986 |
| Drake Hogestyn | John Black | 1986–2024 |
| Kyle Lowder | Brady Black | 2000–2005 |
| Chelsea Butler | Belle Black | 1998–1999 |
| Kirsten Storms | Belle Black | 1999–2004 |
| Charity Rahmer | Belle Black | 2004 |
| Jamie Martin Mann | Tate Black | 2023–2024 |
| Finley Rose Slater | Rachel Black | 2021-2025 |
| Hira Ambrosino | Tori Narita | 2015 |
| Dick Van Dyke | Tim Robicheaux | 2023 |
| Ben Archibek | Neil Curtis | 1973 |
| Joseph Gallison | Neil Curtis | 1974–1991 |
| Gloria Loring | Liz Chandler | 1980–1986, 2024 |
| Joseph Mascolo | Stefano DiMera | 1982–1985, 1988, 1993–2001, 2007–2016 |
| Con Covert | Stefano DiMera | 1984 |
| Frank Fata | Stefano DiMera | 1991 |
| Stephen Nichols | Stefano DiMera | 2019–2020 |
| Eileen Davidson | Susan Banks | 1996–1998, 2014, 2017, 2021 |
| Stacy Haiduk | Susan Banks | 2018–2019, 2021-2024 |
| Madlyn Rhue | Daphne DiMera | 1982-1984 |
| Thaao Penghlis | André DiMera | 1983–1984, 1993–1996, 2002–2005, 2007, 2015–2019, 2022 |
| Eileen Davidson | Kristen DiMera | 1993–1998, 2012–2015, 2017, 2021 |
| James Scott | EJ DiMera | 2006–2014 |
| Casey Deidrick | Chad DiMera | 2009–2013 |
| Tyler Christopher | Stefan DiMera | 2017–2019 |
| Brandon Barash | Stefan DiMera | 2019, 2022-2024 |
| Brandon Barash | Jake DiMera | 2020–2023 |
| Philece Sampler | Renée DuMonde DiMera | 1981–1984 |
| Miranda Wilson | Megan Hathaway DiMera | 1984-1985, 2022-2023 |
| Peter Porte | Dimitri von Leuschner | 2023 |
| Justin Allan | Thomas DiMera | 2018 |
| Asher Morrissette | Thomas DiMera | 2018–2019 |
| Marj Dusay | Vivian Alamain | 1993 |
| Robin Strasser | Vivian Alamain | 2019 |
| Linda Dano | Vivian Alamain | 2021 |
| Cyndi James Gossett | Lexie Carver | 1987–1989 |
| Angelique Francis | Lexie Carver | 1989–1990, 1992 |
| Shellye Broughton | Lexie Carver | 1993 |
| Renee Jones | Lexie Carver | 1993–2012 |
| Jennifer Lee | Lexie Carver | 2021 |
| Kavi Faquir | Theo Carver | 2006–2008 |
| Terrell Ranson Jr. | Theo Carver | 2008–2015 |
| Kyler Pettis | Theo Carver | 2015–2018 |
| Cameron Johnson | Theo Carver | 2020–2023 |
| George DelHoyo | Orpheus | 1986-1987, 2016, 2020-2023 |
| Brock Kelly | Evan Frears | 2019–2022 |
| Marla Adams | Claire McIntyre | 1999 |
| Darrell Thomas Utley | Benjy Hawk | 1988–1990 |
| Jim Lunsford | Benjy Hawk | 2006–2007 |
| Pat Delany | Rachel Blake | 1995-1996 |
| Ann Hamilton | Rachel Blake | 1995-1996 |
| Roslyn Gentle | Rachel Blake | 2025 |
| Jason Brooks | Peter Blake | 1993–1998 |
| Genie Francis | Diana Colville | 1987-1989 |
| Judith Chapman | Diana Colville | 2019, 2024 |
| Andrea Hall | Samantha Evans | 1977–1982 |
| Deidre Hall | Samantha Evans | 1992–2008 |
| Andrea Hall | Hattie Adams | 2000–2001 |
| Barbara Crampton | Trista Evans | 1983-1984 |
| Valerie Wildman | Fay Walker | 1999-2003, 2009-2011 |
| Matt Cedeno | Brandon Walker | 1999–2005 |
| Arianne Zucker | Nicole Walker | 1998–2006, 2008–2018, 2019-2024 |
| Katherine Ellis | Taylor Walker | 1998–1999 |
| Natalia Livingston | Taylor Walker | 2011 |
| Tamara Braun | Taylor Walker | 2011 |
| Eddie Velez | Paul Mendez | 2001 |
| Marla Gibbs | Olivia Price | 2021–2023 |
| Marilyn McCoo | Tamara Price | 1986-1987, 2019-2020 |
| Precious Way | Chanel Dupree | 2021 |
| Nick Benedict | Curtis Reed | 1993–1995, 1997, 1999–2001 |
| Lisa Rinna | Billie Reed | 1992–1995, 2002–2003, 2012–2013, 2018, 2021 |
| Krista Allen | Billie Reed | 1996–1999 |
| Julie Pinson | Billie Reed | 2004–2008 |
| Patrick Muldoon | Austin Reed | 1992–1995, 2011–2012 |
| Austin Peck | Austin Reed | 1995–2002, 2005–2006, 2017, 2019, 2021 |
| Brenda Benet | Lee DuMonde | 1979–1982 |
| Tanya Boyd | Celeste Perrault | 1994–2007 |
| Beverly Todd | Celeste Perrault | 2012 |
| Kristian Alfonso | Gina Von Amberg | 1998-2001, 2012, 2017, 2019-2020 |
| Jamie Taylor | Greta Von Amberg | 1998 |
| Julianne Morris | Greta Von Amberg | 1998-2002 |
| John Aniston | Victor Kiriakis | 1985–2022 |
| Elaine Princi | Kate Roberts | 1977–1979 |
| Deborah Adair | Kate Roberts | 1993–1995 |
| Vincent Irizarry | Deimos Kiriakis | 2016-2017, 2021 |
| Shane Nicholas | Philip Kiriakis | 1998–1999 |
| Brandon Tyler | Philip Kiriakis | 1999 |
| Jay Kenneth Johnson | Philip Kiriakis | 1999–2002, 2007–2011, 2019-2021 |
| Kyle Brandt | Philip Kiriakis | 2003–2006 |
| Jonathan Thornton | Alex Kiriakis | 1989-1991 |
| Freddie Smith (attore) | Sonny Kiriakis | 2011-2020 |
| Zach Tinker | Sonny Kiriakis | 2022–2024 |
| Denise Alexander | Susan Hunter | 1966–1973 |
| Bennye Gatteys | Susan Hunter | 1973–1976 |
| Jed Allan | Don Craig | 1971–1985 |
| Staci Greason | Isabella Toscano | 1989–1992, 1995, 2000, 2002–2003, 2010 |
| Robin Riker | Bonnie Lockhart | 2000 |
| Kathy Connell | Bonnie Lockhart | 2000–2002 |
| Ian Patrick Williams | David Lockhart | 2000, 2002 |
| William Bumiller | David Lockhart | 2007 |
| Doren Fein | Mimi Lockhart | 1999 |
| Farah Fath | Mimi Lockhart | 1999–2007, 2018 |
| Brody Hutzler | Patrick Lockhart | 2004–2007 |
| Austin Wolff | Connor Lockhart | 1999–2000 |
| Noah G. Segan | Connor Lockhart | 2007 |
| Marie Wilson | Summer Townsend | 2016, 2020 |
| William Utay | Wilhelm Rolf | 1997–2003, 2007–2008, 2017–2021 |
| Richard Wharton | Wilhelm Rolf | 2022–2024 |
| Shawn Christian | Daniel Jonas | 2008–2017, 2020 |
| Martha Nix | Janice Barnes | 1975–1978 |
| Elizabeth Storm | Janice Barnes | 1987–1988 |
| Molly Burnett | Melanie Jonas | 2008–2012, 2014–2016 |
| Elin Alexander | Holly Jonas | 2020–2022 |
| Crystal Chappell | Carly Manning | 1990–1993, 2009–2011 |
| James Luisi | Duke Johnson | 1987, 1990–1992 |
| Joy Garrett | Jo Johnson | 1987-1993 |
| Marilyn McIntyre | Jo Johnson | 1993, 2002-2003, 2005-2007 |
| Judi Evans | Adrienne Johnson | 1986–1991, 2007–2008, 2010–2020 |
| Shayna Rose | Stephanie Johnson | 2006–2007 |
| Shelley Hennig | Stephanie Johnson | 2007–2011, 2017 |
| Jadon Wells | Joey Johnson | 2012–2014 |
| James Lastovic | Joey Johnson | 2015–2017, 2020 |
| Tanner Stein | Joey Johnson | 2022-2023 |
| Lucas Adams | Tripp Johnson | 2017–2024 |
| Robert Alda | Stuart Whyland | 1981–1982 |
| Robert Eliot Canko | Andrew Donovan IV | 1986-1988 |
| Brandon Amber | Andrew Donovan IV | 1988-1989 |
| Justin Page | Andrew Donovan IV | 1989 |
| Sky Rumph | Andrew Donovan IV | 1989-1990 |
| Bradley Michael Pierce | Andrew Donovan IV | 1990-1991 |
| Brian Davila | Andrew Donovan IV | 1991-1992 |
| Charlotte Ross | Eve Donovan | 1987–1991 |
| Kassie DePaiva | Eve Donovan | 2014–2020, 2023 |
| Hannah Taylor Simmons | Theresa Donovan | 1990–1991 |
| Caitlin Wachs | Theresa Donovan | 1992 |
| Gabriella Massari | Theresa Donovan | 1992 |
| Jen Lilley | Theresa Donovan | 2013–2016, 2018, 2023 |
| Steve Burton | Harris Michaels | 1988, 2023–2024 |
| Richard Biggs | Marcus Hunter | 1987–1992 |
| Aketra Sevillian | Talia Hunter | 2023 |
| Antony Alda | Johnny Corelli | 1990-1991 |
| Sarah Aldrich | Jill Stevens | 1996–1997 |
| Kevin Spirtas | Craig Wesley | 1997–2003, 2005, 2009, 2022 |
| Patrika Darbo | Nancy Wesley | 1998–2005, 2013, 2016–2017, 2019, 2022, 2024 |
| Nadia Bjorlin | Chloe Lane | 1999–2005, 2007–2011, 2013, 2015–2023 |
| Aisling Acuna | Joy Wesley | 2003, 2005 |
| Natalie Ramsey | Jan Spears | 1999 |
| Heather Lauren Olson | Jan Spears | 1999–2004 |
| Heather Lindell | Jan Spears | 2004–2005, 2020–2022 |
| Ivan G'Vera | Ivan Marais | 1992–2000, 2011, 2020–2021, 2024 |
| Joe Penny. | Martino Vitali | 2008 |
| Angelo Tiffe | Angelo Vitali | 2008, 2017, 2021 |
| A Martinez | Eduardo Hernandez | 2015–2017, 2020 |
| Alma Delfina | Adrianna Hernandez | 2016 |
| Felisha Terrell | Arianna Hernandez | 2009 |
| Lindsay Hartley | Arianna Hernandez | 2009-2010 |
| Francisco San Martin | Dario Hernandez | 2011 |
| Jordi Vilasuso | Dario Hernandez | 2016–2017 |
| Gabriela Rodriguez | Gabi Hernandez | 2009–2010 |
| Camila Banus | Gabi Hernandez | 2010–2023 |
| True O'Brien | Paige Larson | 2014–2015, 2017, 2020 |
| Taylor Spreitler | Mia McCormick | 2009–2010 |
| Daniel Cosgrove | Aiden Jennings | 2014–2016 |
| Connor Kalopsis | Chase Jennings | 2014-2015 |
| Jonathon McClendon | Chase Jennings | 2015-2016 |
| Donald Li | Wei Shin | 2014 |
| Michael Hagiwara | Wei Shin | 2019 |
| Clyde Kusatsu | Wei Shin | 2022-2023 |
| Remington Hoffman | Li Shin | 2019–2024 |
| Victoria Grace | Wendy Shin | 2022–2024 |
| Melissa Archer | Serena Mason | 2014–2015, 2017 |
| Alisa Alapach | Annabelle | 2016 |
| Siena Goines | Simone Michaels | 2016 |
| Real Andrews | Hal Michaels | 2016–2017 |
| Paige Searcy | Jade Michaels | 2016-2017 |
| Gabrielle Haugh | Jade Michaels | 2017 |
| Mike Manning | Charlie Dale | 2020–2022 |
| James Read | Clyde Weston | 2014–2024 |
| Justin Gaston | Ben Weston | 2014 |
| Robert Scott Wilson | Ben Weston | 2014–2023 |
| Chrishell Hartley | Jordan Ridgeway | 2013–2015, 2019–2020 |
| Laura Kai Chen | Melinda Trask | 2013, 2016–2019 |
| Thia Megia | Haley Chen | 2018–2020 |
| Jessica Serfaty | Sloan Petersen | 2022–2024 |
| Natasha Hall | Sloan Petersen | 2024 |
| Jasper Newman | Colin Bedford | 2023 |
| John Kapelos | Konstantin Meleounis | 2023–2024 |
| Blake Berris | Everett Lynch | 2023–2024 |
| Erin Wu | Alana | 2024 |
| Christy St. John | Rebecca Goldman | 2024 |
| Julie Dove | Connie Viniski | 2024 |
| Ellie Patrikios | Catharina Greene | 2024 |
| Susan Elena Matus | Catharina Greene | 2024 |
| Madelyn Kientz | Sophia Choi | 2024–2025 |
| Serena Scott Thomas | Fiona Cook | 2024 |
