Vincent Phillip D'Onofrio (lahir 30 Juni 1959) merupakan seorang aktor berkebangsaan Amerika Serikat. Dia pertama kali berkarier di dunia film sejak tahun 1983. Dia dilahirkan di Brooklyn, New York, Amerika Serikat.
- The First Turn-On! (1983)
- It Don't Pay to Be an Honest Citizen (1984)
- Full Metal Jacket (1987)
- Adventures in Babysitting (1987)
- Mystic Pizza (1988)
- Signs of Life (1989)
- The Blood of Heroes (1989) - also known as Salute of the Jugger
- Crooked Hearts (1991)
- Dying Young (1991)
- Fires Within (1991)
- Naked Tango (1991)
- JFK (1991)
- The Player (1992)
- Salt on Our Skin (1992) - also known as Desire
- Being Human (1993)
- Household Saints (1993)
- Mr. Wonderful (1993)
- Ed Wood (1994)
- The Investigator (1994)
- Imaginary Crimes (1994)
- Nunzio's Second Cousin [1994)
- Stuart Saves His Family (1995)
- Strange Days (1995)
- Hotel Paradise (1995)
- The Whole Wide World (1996)
- The Winner (1996)
- Feeling Minnesota (1996)
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- Good Luck (1996)
- Boys Life 2 (1997)
- Men in Black (1997)
- Guy (1997)
- The Taking of Pelham One Two Three (1998) - TV remake of the 1974 film
- The Newton Boys (1998)
- Claire Dolan (1998)
- The Velocity of Gary (1998)
- Spanish Judges (1999)
- The Thirteenth Floor (1999)
- That Championship Season (1999)
- Happy Accidents (2000)
- Steal This Movie (2000)
- The Cell (2000)
- Chelsea Walls (2001)
- Imposter (2002)
- Bark! (2002)
- The Dangerous Lives of Altar Boys (2002)
- The Red Sneakers (2002)
- The Salton Sea (2002)
- Case of Evil (2002)
- Thumbsucker (2005)
- Five Minutes, Mr Welles (2005)
- The Break Up (2006)
- The Narrows (scheduled for a 2008 release)
- Staten Island (in pre-production)
- Fire With Fire (2012)
- Chained (2012)
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Televisi
- Law & Order: Criminal Intent (2001—) sebagai Det. Robert Goren
- Men in Black: The Series sebagai Bugs (voice) di "The Big Bad Bug Syndrome" (Episode 2.5)
- Homicide: Life on the Street sebagai John Lange di "The Subway" (Episode 6.7)
- The Equalizer sebagai Davy Baylor in "Suspicion of Innocence" (Episode 3.3) dan sebagai Thomas Marley di "Counterfire" (Episode 2.7)
- Miami Vice sebagai Leon Wolf di "The Afternoon Plane" (Episode 3.17)
Dokumentari
- Anatomy of a Homicide, PBS (1998)[1]