O produto proteico do ITGB3 é unha cadea beta beta 3 de integrina. As integrinas son proteínas integrais da superficie celular compostas por unha cadea alfa e unha beta. Unha determinada cadea pode combinarse con diversas moléculas orixinando distintos tipos de integrinas. A integrina beta 3 está combinada coa cadea alfa IIb nas plaquetas. As integrinas participan na adhesión celular e na sinalización celular mediada pola superficie celular.[2]
A expresión defectiva da subunidade β3 de integrina foi correlacionada coa endometriose, e propúxose como un posible marcador para esta doenza.[3]
May, K. E.; Villar, J.; Kirtley, S.; Kennedy, S. H.; Becker, C. M. (2011). "Endometrial alterations in endometriosis: A systematic review of putative biomarkers". Human Reproduction Update 17 (5): 637–653. doi:10.1093/humupd/dmr013. PMID 21672902.
Chung, J; Gao A G, Frazier W A (1997). "Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3". J. Biol. Chem. (UNITED STATES) 272 (23): 14740–6. ISSN0021-9258. PMID9169439. doi:10.1074/jbc.272.23.14740.
Patil, S; Jedsadayanmata A, Wencel-Drake J D, Wang W, Knezevic I, Lam S C (1999). "Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail". J. Biol. Chem. (UNITED STATES) 274 (40): 28575–83. ISSN0021-9258. PMID10497223. doi:10.1074/jbc.274.40.28575.
Calderwood, David A; Yan Boxu, de Pereda Jose M, Alvarez Begoña García, Fujioka Yosuke, Liddington Robert C, Ginsberg Mark H (2002). "The phosphotyrosine binding-like domain of talin activates integrins". J. Biol. Chem. (United States) 277 (24): 21749–58. ISSN0021-9258. PMID11932255. doi:10.1074/jbc.M111996200.
Naik, U P; Patel P M, Parise L V (1997). "Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain". J. Biol. Chem. (UNITED STATES) 272 (8): 4651–4. ISSN0021-9258. PMID9030514. doi:10.1074/jbc.272.8.4651.
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Glicoproteína IIb/IIIa
Bibliografía
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