Voriconazole
Triazole antifungical drug / From Wikipedia, the free encyclopedia
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Voriconazole, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections.[4] This includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by Scedosporium or Fusarium.[4] It can be taken by mouth or used by injection into a vein.[4]
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Pronunciation | /vɒrɪˈkɒnəzoʊl/ vorr-i-KON-ə-zohl |
Trade names | Vfend, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a605022 |
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Routes of administration | Intravenous, by mouth |
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Bioavailability | 96% (oral) |
Protein binding | 58% |
Metabolism | Liver: CYP2C19 (significant involvement), also CYP2C9, CYP3A4 |
Metabolites | Voriconazole N-oxide (major; minimal antifungal activity) |
Elimination half-life | Dose-dependent |
Excretion | Urine (80–83%)[3] |
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ECHA InfoCard | 100.157.870 |
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Formula | C16H14F3N5O |
Molar mass | 349.317 g·mol−1 |
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Common side effects include vision problems, nausea, abdominal pain, rash, headache, and seeing or hearing things that are not present.[4] Use during pregnancy may result in harm to the baby.[4] It is in the triazole family of medications.[4] It works by affecting fungal metabolism and fungal cell membranes.[4]
Voriconazole was patented in 1990 and approved for medical use in the United States in 2002.[5][6] It is on the World Health Organization's List of Essential Medicines.[7]