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Ticlopidine
Chemical compound / From Wikipedia, the free encyclopedia
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Ticlopidine, sold under the brand name Ticlid, is a medication used to reduce the risk of thrombotic strokes.[1] It is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. Research initially showed that it was useful for preventing strokes and coronary stent occlusions. However, because of its rare but serious side effects of neutropenia and thrombotic microangiopathy it was primarily used in patients in whom aspirin was not tolerated, or in whom dual antiplatelet therapy was desirable. With the advent of newer and safer antiplatelet drugs such as clopidogrel and ticagrelor, its use remained limited.
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Trade names | Ticlid |
AHFS/Drugs.com | Monograph |
MedlinePlus | a695036 |
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Routes of administration | By mouth |
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Bioavailability | >80% |
Protein binding | 98% |
Metabolism | Liver |
Elimination half-life | 12 hours (single dose) 4–5 days (repeated dosing) |
Excretion | Kidney and fecal |
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ECHA InfoCard | 100.054.071 ![]() |
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Formula | C14H14ClNS |
Molar mass | 263.78 g·mol−1 |
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It was patented in 1973 and approved for medical use in 1978.[5]