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Stavudine
Chemical compound / From Wikipedia, the free encyclopedia
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Stavudine (d4T), sold under the brand name Zerit among others, is an antiretroviral medication used to prevent and treat HIV/AIDS.[4] It is generally recommended for use with other antiretrovirals.[4] It may be used for prevention after a needlestick injury or other potential exposure.[4] However, it is not a first-line treatment.[4] It is given by mouth.[4]
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Trade names | Zerit |
Other names | 2′,3′-didehydro-2′,3′-dideoxythymidine |
AHFS/Drugs.com | Monograph |
MedlinePlus | a694033 |
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Routes of administration | By mouth |
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Bioavailability | >80% |
Protein binding | Negligible |
Metabolism | Kidney elimination (~40%) |
Elimination half-life | 0.8–1.5 hours (in adults) |
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ECHA InfoCard | 100.169.180 ![]() |
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Formula | C10H12N2O4 |
Molar mass | 224.216 g·mol−1 |
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Common side effects include headache, diarrhea, vomiting, rash, and peripheral nerve problems.[4] Severe side effects include high blood lactate, pancreatitis, and an enlarged liver.[4] It is not generally recommended in pregnancy.[4] Stavudine is in the nucleoside analog reverse-transcriptase inhibitor (NRTI) class of medication.[4]
Stavudine was first described in 1966 and approved for use in the United States in 1994.[5] It is available as a generic medication.[4]