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Sertindole
Antipsychotic medication / From Wikipedia, the free encyclopedia
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Sertindole, sold under the brand name Serdolect among others, is an antipsychotic medication. Sertindole was developed by the Danish pharmaceutical company Lundbeck and marketed under license by Abbott Labs. Like other atypical antipsychotics, it has activity at dopamine and serotonin receptors in the brain. It is used in the treatment of schizophrenia. It is classified chemically as a phenylindole derivative.
Quick Facts Clinical data, Trade names ...
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Trade names | Serdolect, Serlect |
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Routes of administration | By mouth |
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Bioavailability | 75%[1] |
Protein binding | 99.5%[1] |
Metabolism | Liver (mostly via CYP2D6 and CYP3A4)[2][3] |
Elimination half-life | 3 days[2] |
Excretion | Faecal (the majority), Kidney (4% metabolites; 1% unchanged)[2] |
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ECHA InfoCard | 100.162.562 ![]() |
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Formula | C24H26ClFN4O |
Molar mass | 440.95 g·mol−1 |
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Sertindole is not approved for use in the United States and was discontinued in Australia in January 2014.[citation needed]