Wissahickon is a neighborhood in the section of Lower Northwest Philadelphia in the state of Pennsylvania, United States. Wissahickon is located adjacent to the neighborhoods of Roxborough and Manayunk, and it is bounded by the Wissahickon Valley Park, Ridge Avenue, Hermit Street, and Henry Avenue. The name of the neighborhood is derived from the Lenni Lenape word wisameckham, for "catfish creek", a reference to the fish that were once plentiful in the Wissahickon Creek.