Wilkes-Barre is a city in and the county seat of Luzerne County, Pennsylvania, United States. Located at the center of the Wyoming Valley in Northeastern Pennsylvania, it had a population of 44,328 in the 2020 census. It is the second-largest city, after Scranton, in the Scranton–Wilkes-Barre–Hazleton, PA Metropolitan Statistical Area, which had a population of 567,559 as of the 2020 census, making it the fifth-largest metropolitan area in Pennsylvania after the Delaware Valley, Greater Pittsburgh, the Lehigh Valley, and Greater Harrisburg.