West Little Owyhee River is a 63.1-mile-long (101.5 km) tributary of the Owyhee River in the U.S. state of Oregon. The source of the river is at an elevation of 6,508 feet (1,984 m) near McDermitt, while the mouth is at an elevation of 4,373 feet (1,333 m) in the Owyhee Desert. West Little Owyhee River has a 310-square-mile (800 km2) watershed.