Vyssa is a former municipality in the Evros regional unit, East Macedonia and Thrace, Greece. Since the 2011 local government reform it is part of the municipality Orestiada, of which it is a municipal unit. The municipal unit has an area of 170.179 km2. Population 4,378 (2021). The seat of the municipality was in Nea Vyssa. It is named after a former village 4 km (2 mi) to its north that is now in Turkey. Refugees from that side fled into this area and settled into these villages.