USS Keokuk was an experimental ironclad screw steamer of the United States Navy named for the city of Keokuk, Iowa. She was laid down in New York City by designer Charles W. Whitney at J.S. Underhill Shipbuilders, at the head of 11th Street. She was originally named Moodna, but was renamed while under construction, launched in December 1862 sponsored by Mrs. C. W. Whitney, wife of the builder, and commissioned in early March 1863 with Commander Alexander C. Rhind in command.