U.S. Route 90 or U.S. Highway 90 (US 90) is an east–west major United States highway in the Southern United States. Despite the "0" in its route number, US 90 never was a full coast-to-coast route. It generally travels near Interstate 10 (I-10) and passes through the southern states of Texas, Louisiana, Mississippi, Alabama, and Florida. US 90 also includes part of the DeSoto Trail between Tallahassee and Lake City, Florida.