Tsholotsho, originally known as Tjolotjo, is a district in Matabeleland North province in Zimbabwe. Its administrative centre is at Tsholotsho business centre which is located about 98 km north-west of Bulawayo. Districts around Tsholotsho include Lupane, Hwange, Umguza, and Bulilima. The Manzamnyama River separates Tsholotsho from Bulilima District, whilst the Gwayi River separates it from Umguza and Lupane districts, and the Hwange National Park separates it from Hwange District.