St Joseph's Orphanage is a Grade II listed former orphanage and hospital complex in Preston, Lancashire, England. The complex is located on Theatre Street and Mount Street. The orphanage was constructed and opened in 1872 and a hospital extension was opened in 1877. In more recent years the complex was used as a private care home but that closed in 2003. The complex also includes a tower. The building later became derelict until 2022 when demolition began following redevelopment plans.