Srey Santhor is a district (srok) located in Kampong Cham province, Cambodia. The district capital is Srey Santhor town located on the south bank of the Mekong River around midway between Phnom Penh and the provincial capital of Kampong Cham. Srey Santhor is in south western Kampong Cham and lies on the border with Kandal and Prey Veng provinces. It was briefly the capital of Cambodia during the post-Angkor era from 1431 to 1434. During the Middle Period, it was then known as Srey Sarchhor.