Smithers Creek is a tributary of the Kanawha River, 7 miles (11 km) long, in southern West Virginia in the United States. Via the Kanawha and Ohio rivers, it is part of the watershed of the Mississippi River, draining an area of 18.1 square miles (47 km2) on the unglaciated portion of the Allegheny Plateau. The creek flows for its entire length in western Fayette County; its tributaries additionally drain a portion of eastern Kanawha County.