The Sherman House was a hotel in Chicago, Illinois that operated from 1837 until 1973, with four iterations standing at the same site at the northwest corner of Randolph Street and Clark Street. Long one of the city's major hotels, the hotel's fortunes declined in the 1950s amid changes to its surrounding area, and it closed in 1973. The fourth and final building it had occupied was demolished in 1980 to make room for the James R. Thompson Center.