The Schermerhorn Building is a historic structure at 376–380 Lafayette Street, on the northwest corner with Great Jones Street, in the NoHo neighborhood of Manhattan in New York City. It was built in 1888–1889 by William C. Schermerhorn on the site of the Schermerhorn mansion, and rented by him to a boys' clothing manufacturer. The Romanesque Revival loft building was designed by Henry Hardenbergh, architect of the Plaza Hotel and The Dakota. The building is constructed of brownstone, sandstone, terra-cotta and wood, and has dwarf columns made of marble.