Rufino is a city in the province of Santa Fe, Argentina. It has 18,980 inhabitants as per the 2010 census [INDEC]. It lies on the southwest of the province, 260 km (162 mi) from the main metropolitan area of the province Greater Rosario,416 km (258 mi) from the provincial capital Santa Fe, near the borders with Córdoba (west) and Buenos Aires (south), on the intersection of National Routes 33 and 7.