Roanoke is an independent city in the Commonwealth of Virginia in the United States. It is located in Southwest Virginia along the Roanoke River, in the Blue Ridge range of the greater Appalachian Mountains. Roanoke is approximately 50 miles (80 km) north of the Virginia–North Carolina border and 250 miles (400 km) southwest of Washington, D.C., along Interstate 81. At the 2020 census, Roanoke's population was 100,011, making it the most-populous city in Virginia west of the state capital Richmond. It is the primary population center of the Roanoke metropolitan area, which had a population of 315,251 in 2020.