Punta Guaniquilla is a headland or small peninsula located immediately to the south of Buyé Beach and north of Boquerón Bay in the municipality of Cabo Rojo, Puerto Rico. The entirety of the headland is protected as the Punta Guaniquilla Nature Reserve by the Conservation Trust of Puerto Rico and the Puerto Rico Department of Natural and Environmental Resources since 1977, making it one of the oldest nature reserves officially protected by Puerto Rico Law #150.