The Preston House, also known as the Palmer House, was a historic home located at Saltville, Smyth County, Virginia. The original section was built about 1795. It was a two-story, gable-roofed, double-pile frame structure covered with beaded weatherboard. It consisted of a two-story, five bay center section flanked by later, and lower, two-story, three bay flanking wings. The house was built by lawyer and politician Francis Preston (1765–1836), whose family owned the salt works. The house was destroyed in 1978.