The Pra River is a river in Ghana, the easternmost and the largest of the three principal rivers that drain the area south of the Volta divide. Rising in the Kwahu Plateau near Mpraeso and flowing southward for 240 km through rich cocoa and farming areas and valuable forests in the Akan lowlands, the Pra enters the Gulf of Guinea east of Takoradi. In the 19th century, the Pra served as the border between the Ashanti Confederacy and the Gold Coast.