Mühlendamm is a major thoroughfare in the central Mitte district of Berlin, Germany. It runs from the historic Cölln and Fischerinsel quarters to the Molkenmarkt square of Alt-Berlin via the Mühlendammbrücke crossing the Spree river. Named after several watermills at the site, a historic causeway was first laid out at this location about 1200 and became the nucleus of the late medieval city foundation. The current prestressed concrete bridge was built in 1968. It is part of an east–west road link to Berlin's city centre and the Bundesstraße 1 highway.