Mozolice Duże is a village in the administrative district of Gmina Sieciechów, within Kozienice County, Masovian Voivodeship, in east-central Poland. It lies approximately 3 kilometres (2 mi) north-west of Sieciechów, 10 km (6 mi) east of Kozienice, and 89 km (55 mi) south-east of Warsaw, on the national road DK 48.