Milo is a town in Piscataquis County, Maine, United States. The population was 2,251 at the 2020 census. Milo includes the village of Derby. The town sits in the valley of the Piscataquis, Sebec and Pleasant Rivers in the foothills of the Longfellow Mountains and is the gateway to many pristine hunting, fishing, hiking, boating, and other outdoor tourist locations such as Schoodic, Seboeis, and Sebec Lakes, Mount Katahdin and its backcountry in Baxter State Park and the Katahdin Woods and Waters National Monument, Katahdin Iron Works and Gulf Hagas.