Middletown was the main station along the Erie Railroad mainline in the city of Middletown, New York. Located on Depot Street, the station was first opened in 1843 with the construction of the New York, Lake Erie and Western Railroad, which had originally terminated at Goshen. The station was located along the New York Division, which stretched from Pavonia Terminal in Jersey City, New Jersey, to the Sparrowbush station just north of Port Jervis.