Mayo Clinic Square on Block E in downtown Minneapolis, is a building bounded by Hennepin Avenue, North 6th Street, North 7th Street, and 1st Avenue North. It is part of the Downtown West neighborhood in Minneapolis, historically known as the Warehouse District. It is one block south of the Warehouse District/Hennepin Avenue light rail station on the METRO Blue and Green lines. "Block E" is a City planning department designation of the block; other blocks have similar designations