Manzini is a region of Eswatini, located in the center-west of the country. It has an area of 4,093.59 km2 and a population of 355,945 (2017). Its administrative center is Manzini. It borders all three other regions of Eswatini: Hhohho in the north, Lubombo in the east, and Shiselweni in the south. It is bordered by the Mpumalanga province in South Africa to the west.