Manyoni District is one of the six districts in the Singida Region of Tanzania. The district capital is the town of Manyoni. The district is bordered to the north by the Ikungi District, to the east by the Dodoma Region, to the south by the Iringa Region, to the southwest by the Mbeya Region and to the west by the Itigi District. In 2015 the Itigi District was created from the Manyoni District, separating the Itigi Division that was the large portion of the south western of the district.