Itajaí is a municipality in the state of Santa Catarina, Brazil. It is located on the northern central coast of Santa Catarina and is part of the Vale do Itajaí Mesoregion, on the right bank of the Itajaí-Açu river mouth. It lies at the mouth of the Itajaí River, at 20 feet above sea level. The city has the 2nd largest gross domestic product and the highest per capita income in the State of Santa Catarina.