The Igreja de São Roque is a Catholic church in Lisbon, Portugal. It was the earliest Jesuit church in the Portuguese world, and one of the first Jesuit churches anywhere. The edifice served as the Society's home church in Portugal for over 200 years, before the Jesuits were expelled from that country. After the 1755 Lisbon earthquake, the church and its ancillary residence were given to the Lisbon Holy House of Mercy to replace their church and headquarters which had been destroyed. It remains a part of the Holy House of Mercy today, one of its many heritage buildings.