First Presbyterian Church is a historic Presbyterian Church located at Niagara Falls, Niagara County, New York. The original section was built in 1849, with additions and modifications made in 1879, 1903–1904, and 1921. The sanctuary was renovated in 1957. It is a Gothic Revival style, L-shaped, stone church. The church features a three-story crenellated bell tower and round arched windows and openings. The congregation was established in 1824.