Elsmere is a hamlet of the town of the Bethlehem in Albany County, New York, United States. The hamlet is a suburb of the neighboring city of Albany. From the northeast to the southwest, it is bisected by New York Route 443, which is also the hamlet's main street and a major commuter route into Albany. Delaware Avenue is also home to most of the office and retail locations in Elsmere, including the largest such location: Delaware Plaza.