Edwards Run is a 7.9-mile-long (12.7 km) tributary stream of the Cacapon River, belonging to the Potomac River and Chesapeake Bay watersheds. The stream is located in Hampshire County in the U.S. state of West Virginia's Eastern Panhandle. Edwards Run is named for Joseph Edwards and his family, whose plantation encompassed most of the stream's course. George Washington surveyed his property in the late 1740s. It is a major source of various species of elodea.