Chake Chake District is one of two administrative districts of Pemba South Region in Tanzania. The district covers an area of 219 km2 (85 sq mi). The district is comparable in size to the land area of American Samoa. The district has a water border to the east and west by the Indian Ocean. The district is bordered to the south by Mkoani District and the north by Wete District of Pemba North Region. The district seat (capital) is the town of Chake-Chake. According to the 2022 census, the district has a total population of 136,298.