Bethany Historic District is a national historic district located at Bethany, Brooke County, West Virginia. It encompasses 111 contributing buildings on the campus of Bethany College, the central business district, and surrounding residential areas in Bethany. Notable buildings include the Gothic Revival-style Irvin Gymnasium at Bethany College, Point Breeze Mansion, Old Opera House, Chambers General Store, and the Federal-style Hibernia Hall. Also in the district are a number of residences in popular architectural styles including Late Victorian. Located within the district are the separately listed Alexander Campbell Mansion, Delta Tau Delta Founders House, Old Bethany Church, Old Main, and Pendleton Heights.