The Barnesville Depot is a historic site in Barnesville, Georgia. It was added to the National Register of Historic Places on April 30, 1986. It is located at Plaza Way and Main Street. The station was constructed in 1912 for the Central of Georgia Railway. It is located at the junction of the Central's former Macon-Atlanta mainline and its branch to Thomaston, Georgia. The building includes Spanish or Mission architecture and replaced an earlier stone depot constructed in 1852 by the Macon & Western Railroad. It is now used as an arts center.